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Title   벤조피렌 , 디메칠니트로사민 및 디부틸니트로사민에 의한 마우스 다장기 발암모델 확립에 관한 연구 ( Lack of Multi - Organ Carcinogenesis in Female N : GP(S) Mice by Benzo(a) pyrene , Dimethylnitosamine and Dibutylnitrosamine )
Publicationinfo   1993 Jan; 025(04): 572-578.
Key_word   Wide-spectrum carcinogenesis, Benzo(a)pyrene, Dimethylnitrosamine, Dibutylnitrosamine, N-Methylnitrosourea, Mouse
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Abstract   A wide-spectrum initiation model was investigated in female N: GP(S) mice. Sequential treatments with benzo(a)pyrene (BP), dimethylnitrosamine(DMN) dibutylnitrosamine(DBN), with or without N- methylnitrosourea(MNU), resulted in tu.mor formation in the lungs in 84.2-90.0% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were mainly adenomas and 4 cases showed carcinoma in adenoma. The mean number of adenoma was 13.2-16.2 per mouse. MNU combination had no additive effect on the lung tumor incidence, but significantly increased the lung tumor multiplicity. The carcinogen-treated animals showed cytomegaly of hepatocytes and this was more marked in MNU combined group. These results showed that a wide-spectrum initiation model was not established in this mouse system. Further study with a change in mouse strain or in combination of carcinogen, or increment of carcinogen dose would be necessary.
저 자   이윤실(Yun Sil Lee),조경자(Kyung Ja Cho),장자준(Ja June Jang)